General Information

    • DRAMP ID

    • DRAMP18444

    • Peptide Name

    • Lacrain (myriapods, arthropods, invertebrates, animals)

    • Source

    • Brazilian centipede, Scolopendra viridicornis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RYPAVGYT

    • Sequence Length

    • 8

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.27451089]Gram-negative bacteria : Pseudomonas aeruginosa ATCC 27853 (MIC=5.8 μg/ml;MBC=11.6 μg/ml), Alcaligenes faecalis ATCC 8750 (MIC=5.8 μg/ml;MBC=5.8 μg/ml), Serratia marcescens ATCC 4112 (MIC=5.8 μg/ml;MBC=5.8 μg/ml), Enterobacter cloacae β-12 (MIC=2.9 μg/ml;MBC=2.9 μg/ml), Salmonella serovars (MIC=5.8 μg/ml;MBC=11.6 μg/ml), Salmonella enterica subsp. arizonae (MIC=5.8 μg/ml;MBC=5.8 μg/ml), Escherichia coli SBS363 (MIC=5.8 μg/ml;MBC=5.8 μg/ml), Escherichia coli D31 (MIC=5.8 μg/ml;MBC=5.8 μg/ml)

    • Hemolytic Activity

      • [Ref.27451089] 0% hemolysis at 0.5-500 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18444 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18444.

Physicochemical Information

    • Formula

    • C43H63N11O12

    • Absent Amino Acids

    • CDEFHIKLMNQSW

    • Common Amino Acids

    • Y

    • Mass

    • 926.04

    • PI

    • 8.59

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +1

    • Boman Index

    • -1098

    • Hydrophobicity

    • -0.475

    • Aliphatic Index

    • 48.75

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 425.71

    • Polar Residues

    • 4

DRAMP18444

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Lacrain: the first antimicrobial peptide from the body extract of the Brazilian centipede Scolopendra viridicornis

    • Reference

    • Int J Antimicrob Agents. 2016 Sep;48(3):277-85. doi: 10.1016/j.ijantimicag.2016.05.015.

    • Author

    • E. Chaparro,P.I. da Silva Junior