General Information

    • DRAMP ID

    • DRAMP18445

    • Peptide Name

    • hdMolluscidin (mollusca/molluscs/mollusks, invertebrates, animals; Lys-rich; Ala-rich)

    • Source

    • gill, the abalone, Haliotis discus

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AATKPKKAGAEAAPKKPAKKQTKKKPAKKAGGKKKPKRAGAKKAKK

    • Sequence Length

    • 46

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against B. subtilis KCTC1021, B. subtilis RM125, S. aureus RM4220, E. coli D31, E. coli KCTC1116, P. aeruginosa KCTC2004, S. enterica KCTC2514, S. flexneri KCTC2517 (MIC 0.2-3.9 uM), fish pathogen A. hydrophila KCTC2358, and V. parahemolyticus KCCM41664 (MIC 0.4-0.7 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18445 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18445.

Physicochemical Information

    • Formula

    • C213H390N70O52

    • Absent Amino Acids

    • CDFHILMNSVWY

    • Common Amino Acids

    • K

    • Mass

    • 4763.88

    • PI

    • 11.22

    • Basic Residues

    • 21

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +20

    • Boman Index

    • -11793

    • Hydrophobicity

    • -1.715

    • Aliphatic Index

    • 26.09

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP18445

DRAMP18445 chydropathy plot

Comments Information

    • No hemolysis at 100 ug/mL. May target an intracellular target.

Literature Information

  • ·Literature 1

    • Title

    • Reference

    • Fish Shellfish Immunol. 2016 May;52:289-97.

    • Author

    • Seo JK, Go HJ, Kim CH, Nam BH, Park NG.