General Information

    • DRAMP ID

    • DRAMP18446

    • Peptide Name

    • Gm0026x00785(77

    • Source

    • soybean, Glycine max

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • HKMDLHWYLRTLEEVVIRALQRFQFR

    • Sequence Length

    • 26

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18446 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18446.

Physicochemical Information

    • Formula

    • C156H240N46O36S

    • Absent Amino Acids

    • CGNPS

    • Common Amino Acids

    • LR

    • Mass

    • 3385.98

    • PI

    • 9.97

    • Basic Residues

    • 7

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +4

    • Boman Index

    • -6555

    • Hydrophobicity

    • -0.419

    • Aliphatic Index

    • 97.41

    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 268.85

    • Polar Residues

    • 2

DRAMP18446

DRAMP18446 chydropathy plot

Comments Information

    • It inhibited the in vitro growth of X. axonopodis pv. glycines, the causative agent of the bacterial pustule disease, at 10 uM. Also active ex vivo and in vivo after vector transformation.

Literature Information

  • ·Literature 1

    • Title

    • Probing protein sequences as sources for encrypted antimicrobial peptides.

    • Reference

    • PLoS One. 2012;7(9):e45848.

    • Author

    • Brand GD, Magalh?es MT, Tinoco ML, Arag?o FJ, Nicoli J, Kelly SM, Cooper A, Bloch C Jr.