• DRAMP ID

    • DRAMP18486
    • Peptide Name

    • LAK160-P10
    • Source

    • Synthetic construct
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • KKLKLALAKPALLWKALALKLKKA
    • Sequence Length

    • 24
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Synthetic
    • Biological Activity

    • Antibacterial, Antiplasmodial, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=2.22±0.63 μM), Escherichia coli Top 10 (MIC=0.45±0.24 μM), Pseudomonas aeruginosa (MIC=4.14±0.23 μM)
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Alpha helix
    • Structure Description

    • Unknownn
    • DRAMP18486 helical wheel diagram
    • Formula

    • C130H233N33O25
    • Absent Amino Acids

    • CDEFGHIMNQRSTVY
    • Common Amino Acids

    • KL
    • Mass

    • 306896
    • PI

    • 11.65
    • Basic Residues

    • 8
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 15
    • Boman Index

    • 815
    • Hydrophobicity

    • 31.25
    • Aliphatic Index

    • 155
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 239.13
    • Polar Residues

    • 0

DRAMP18486

DRAMP18486 chydropathy plot
    • Function

    • Antibacterial activity against Gram-negative bacteria.
  • Literature 1
    • Reference

    • J Biol Chem. 2012 Oct 5;287(41):34120-33.
    • Author

    • Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ.
    • Title

    • Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic α-helical peptides.