General Information

    • DRAMP ID

    • DRAMP18488

    • Peptide Name

    • Css54 (Css from the species name below; scorpions, arachnids, Chelicerata, arthropods, invertebra

    • Source

    • Centruroides suffusus (Mexican scorpion)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FFGSLLSLGSKLLPSVFKLFQRKKE

    • Sequence Length

    • 25

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Cytolysis, Hemolytic

    • Target Organism

      • [Ref.23093034]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 μg/ml);
      • Gram-negative bacterium: Escherichia coli (MIC=12.5 μg/ml).

    • Hemolytic Activity

      • [Ref.23093034]30% hemolytic activity at 9 μM, 67% hemolytic activity at 17 μM against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18488 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18488.

Physicochemical Information

    • Formula

    • C138H221N33O33

    • Absent Amino Acids

    • ACDHIMNTWY

    • Common Amino Acids

    • L

    • Mass

    • 2870.47

    • PI

    • 10.46

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +4

    • Boman Index

    • -1571

    • Hydrophobicity

    • 0.22

    • Aliphatic Index

    • 105.2

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP18488

DRAMP18488 chydropathy plot

Comments Information

    • Function

    • Amphipathic peptide that shows antibacterial activity against Escherichia coli and Staphylococcus aureus. Increases efficacy of antibiotics when tested against S.aureus, probably by facilitating their incorporation into the bacteria. Has hemolytic activity against human erythrocytes.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics.

    • Reference

    • J Antibiot (Tokyo). 2013 Jan;66(1):3-10.

    • Author

    • Garcia F, Villegas E, Espino-Solis GP, Rodriguez A, Paniagua-Solis JF, Sandoval-Lopez G, Possani LD, Corzo G.