General Information

    • DRAMP ID

    • DRAMP18489

    • Peptide Name

    • Cathelicidin-PY (Frog, amphibians, animals; BBL)

    • Source

    • Paa yunnanensis(Chinese Yunnan frog)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • Not found

    • Sequence

    • RKCNFLCKLKEKLRTVITSHIDKVLRPQG

    • Sequence Length

    • 29

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-inflammatory

    • Target Organism

      • [Ref.23594231]Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=2.74 µM).

    • Hemolytic Activity

      • [Ref.23594231]2.5% hemolytic activity at 12.5 μg/mL, 3.5 hemolytic activity at 25 μg/mL, 5.5% hemolytic activity at 50 μg/mL against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Helix

    • Structure Description

    • cathelicidin-PY adopts a tertiary structure with a mostly positively charged surface containing a helix (Thr15

    • Helical Wheel Diagram

    • DRAMP18489 helical wheel diagram
  • 2LR7-> 

    • Predicted Structure

    • There is no predicted structure for DRAMP18489.

Physicochemical Information

    • Formula

    • C151H263N47O39S2

    • Absent Amino Acids

    • AMWY

    • Common Amino Acids

    • K

    • Mass

    • 3425.16

    • PI

    • 10.2

    • Basic Residues

    • 9

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +7

    • Boman Index

    • -6934

    • Hydrophobicity

    • -0.483

    • Aliphatic Index

    • 100.69

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.46

    • Polar Residues

    • 7

DRAMP18489

DRAMP18489 chydropathy plot

Comments Information

    • Function

    • Cathelicidin-PY exerted strong antimicrobial abilities and induced little hemolytic activity in a dose-dependent manner.

Literature Information

  • ·Literature 1

    • Title

    • Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide.

    • Reference

    • J Med Chem. 2013 May 9;56(9):3546-56.

    • Author

    • Wei L, Yang J, He X, Mo G, Hong J, Yan X, Lin D, Lai R.