• DRAMP ID

    • DRAMP18489
    • Peptide Name

    • Cathelicidin-PY (Frog, amphibians, animals; BBL)
    • Source

    • Paa yunnanensis(Chinese Yunnan frog)
    • Family

    • Belongs to the cathelicidin family
    • Gene

    • Unknown
    • Sequence

    • RKCNFLCKLKEKLRTVITSHIDKVLRPQG
    • Sequence Length

    • 29
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antimicrobial and Anti-inflammatory. , Anti-Gram+
    • Target Organism

      • [Ref.23594231]Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=2.74 µM).
    • Hemolytic activity

      • [Ref.23594231]2.5% hemolytic activity at 12.5 μg/mL, 3.5 hemolytic activity at 25 μg/mL, 5.5% hemolytic activity at 50 μg/mL against human red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Helix
    • Structure Description

    • cathelicidin-PY adopts a tertiary structure with a mostly positively charged surface containing a helix (Thr15
    • DRAMP18489 helical wheel diagram
    • 2LR7-> 
    • Formula

    • C151H263N47O39S2
    • Absent Amino Acids

    • AMWY
    • Common Amino Acids

    • K
    • Mass

    • 392478
    • PI

    • 10.95
    • Basic Residues

    • 9
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 9
    • Boman Index

    • -6934
    • Hydrophobicity

    • -48.28
    • Aliphatic Index

    • 100.69
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 4.46
    • Polar Residues

    • 7

DRAMP18489

DRAMP18489 chydropathy plot
    • Function

    • Cathelicidin-PY exerted strong antimicrobial abilities and induced little hemolytic activity in a dose-dependent manner.
  • Literature 1
    • Reference

    • J Med Chem. 2013 May 9;56(9):3546-56.
    • Author

    • Wei L, Yang J, He X, Mo G, Hong J, Yan X, Lin D, Lai R.
    • Title

    • Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide.