General Information

    • DRAMP ID

    • DRAMP18493

    • Peptide Name

    • TP3

    • Source

    • Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)

    • Family

    • Piscidin

    • Gene

    • TP3

    • Sequence

    • FIHHIIGGLISVGKHIHGLIHGH

    • Sequence Length

    • 23

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antibacterial, wound healing, immunomodulatory, Anti-Gram+, Antimicrobial

    • Target Organism

      • [Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=256 μg/ml; MBC=256 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC=256 μg/ml; MBC>256 μg/ml);
      • Fungi: Candida albicans (MIC=128 μg/ml; MBC=128 μg/ml)

    • Hemolytic Activity

      • [Ref.29040295] 2% hemolysis at 3.13 μg/ml, 5% hemolysis at 6.25 μg/ml, 10% hemolysis at 12.50 μg/ml, 55% hemolysis at 25.00 μg/ml, 85% hemolysis at 50.00 μg/ml, 100% hemolysis at 100.00 μg/ml against mouse red blood cell

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18493 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18493.

Physicochemical Information

    • Formula

    • C117H182N36O25

    • Absent Amino Acids

    • ACDEMNPQRTWY

    • Common Amino Acids

    • HI

    • Mass

    • 2492.96

    • PI

    • 8.79

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +7

    • Boman Index

    • 1417

    • Hydrophobicity

    • 0.683

    • Aliphatic Index

    • 148.26

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP18493

DRAMP18493 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive bacteria. Antifungal activity. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4.

    • Reference

    • PLoS One. 2017 Oct 17;12(10):e0186442.

    • Author

    • Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD.