General Information

    • DRAMP ID

    • DRAMP18497

    • Peptide Name

    • TSG-6 (Ixosin-B peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from Ixosin-B

    • Gene

    • Not found

    • Sequence

    • WKSDVRRWRSRY

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.23570790]Gram-positive bacteria: Staphylococcus aureus (MIC>100 μM);
      • Gram-negative bacteria: Escherichia coli (MIC=64 μM), Pseudomonas aeruginosa (MIC>100 μM)

    • Hemolytic Activity

      • [Ref.23570790]0.3±0.9% hemolysis at 100μM against human red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18497 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C76H115N27O18

    • Absent Amino Acids

    • ACEFGHILMNPQT

    • Common Amino Acids

    • R

    • Mass

    • 1694.92

    • PI

    • 11.55

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +4

    • Boman Index

    • -7219

    • Hydrophobicity

    • -2.158

    • Aliphatic Index

    • 24.17

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 12490

    • Absorbance 280nm

    • 1135.45

    • Polar Residues

    • 3

DRAMP18497

Comments Information

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity,

Literature Information

  • ·Literature 1

    • Title

    • Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.

    • Reference

    • Bioorg Med Chem Lett. 2013 May 15;23(10):2929-32.

    • Author

    • Wu YS, Liao ZJ, Wang KS, Lung FD.