General Information

    • DRAMP ID

    • DRAMP18504

    • Peptide Name

    • E(AU)2 (Aurein 1.2 peptide derivative)

    • Source

    • Litoria raniformis (Southern bell frog)

    • Family

    • Derived from Aurein 1.2

    • Gene

    • Not found

    • Sequence

    • FSEAIKKIIDFLGEGLFDIIKKIAESF

    • Sequence Length

    • 27

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.23519707]Gram-negative bacterium: Escherichia coli (MIC=128 μmol/L)

    • Hemolytic Activity

      • [Ref.23519707]~5% hemolysis at 128μmol/L, 0% hemolysis at 4 -32μmol/L against human red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Coiled coil

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18504 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C147H231N31O40

    • Absent Amino Acids

    • CHMNPQRTVWY

    • Common Amino Acids

    • I

    • Mass

    • 3072.63

    • PI

    • 4.94

    • Basic Residues

    • 4

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 14

    • Net Charge

    • -1

    • Boman Index

    • -1009

    • Hydrophobicity

    • 0.515

    • Aliphatic Index

    • 122.96

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP18504

DRAMP18504 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria, E(AU)2 has no hemolytic activity

Literature Information

  • ·Literature 1

    • Title

    • Dimerization of aurein 1.2: effects in structure, antimicrobial activity and aggregation of C?ndida albicans cells

    • Reference

    • Amino Acids. 2013 Jun;44(6):1521-8.

    • Author

    • Lorenzón EN, Sanches PR, Nogueira LG, Bauab TM, Cilli EM.