General Information
-
DRAMP ID
- DRAMP18512
-
Peptide Name
- D-LAK120-A
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- KKLALALAKKWLALAKKLALALAKK
-
Sequence Length
- 25
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial
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Target Organism
-
- [Ref.22869378]Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.23±0.47 μM), Escherichia coli Top 10 (MIC=0.38±0.21 μM), Pseudomonas aeruginosa (MIC=1.83±0.63 μM);
- Plasmodium: Plasmodium falciparum 3D7 (EC50=1.45±0.12 μM), Plasmodium falciparum C10 (EC50=2.13±0.14 μM), A549 (EC50=5.23±0.35 μM), RAW264.7 (EC50=7.31±2.13 μM)
-
Hemolytic Activity
-
- [Ref.22869378]HC50=17.42±2.17 μM against Not found (The literature does not mention)
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18512.
Physicochemical Information
-
Formula
- C131H236N34O26
Absent Amino Acids
- CDEFGHIMNPQRSTVY
Common Amino Acids
- AKL
Mass
- 2703.53
PI
- 10.85
Basic Residues
- 8
Acidic Residues
- 0
Hydrophobic Residues
- 17
Net Charge
- +8
-
Boman Index
- 1177
Hydrophobicity
- 0.508
Aliphatic Index
- 156.8
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 229.17
Polar Residues
- 0
DRAMP18512
Comments Information
Function
- Antibacterial activity against Gram-negative bacteria. Antiplasmodial activity. Peptides comprising all D-amino acids. Has hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic
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Pubmed ID
- 22869378
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Reference
- J Biol Chem. 2012 Oct 5;287(41):34120-33.
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Author
- Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ.