General Information

    • DRAMP ID

    • DRAMP18514

    • Peptide Name

    • D-LAK120-H

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KKLALHALKKWLHALKKLAHLALKK

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial

    • Target Organism

      • [Ref.22869378]Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.54±0.01 μM), Escherichia coli Top 10 (MIC=0.40±0.01 μM), Pseudomonas aeruginosa (MIC=1.35±0.07 μM);
      • Plasmodium: Plasmodium falciparum 3D7 (EC50=1.26±0.14 μM), Plasmodium falciparum C10 (EC50=4.43±0.33 μM), A549 (EC50=4.54±0.30 μM), RAW264.7 (EC50=5.21±0.57 μM)

    • Hemolytic Activity

      • [Ref.22869378]HC50=20.29±2.42 μM against Not found (The literature does not mention)

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18514 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18514.

Physicochemical Information

    • Formula

    • C140H242N40O26

    • Absent Amino Acids

    • CDEFGIMNPQRSTVY

    • Common Amino Acids

    • KL

    • Mass

    • 2901.71

    • PI

    • 10.85

    • Basic Residues

    • 11

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +11

    • Boman Index

    • -764

    • Hydrophobicity

    • -0.092

    • Aliphatic Index

    • 144.8

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 229.17

    • Polar Residues

    • 0

DRAMP18514

DRAMP18514 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria. Antiplasmodial activity. Peptides comprising all D-amino acids. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic

    • Reference

    • J Biol Chem. 2012 Oct 5;287(41):34120-33.

    • Author

    • Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ.