General Information
-
DRAMP ID
- DRAMP18522
-
Peptide Name
- K7D/K10D/K14D/K22D (A12L/A20L peptide derivative)
-
Source
- Synthetic construct
-
Family
- Derived from the framework peptide A12L/A20L
-
Gene
- Not found
-
Sequence
- KWKSFLkTFkSLKkTVLHTLLkAISS
-
Sequence Length
- 26
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Anti-Cancer
-
Target Organism
-
- [Ref.22837667]Cancer cell: HeLa cell (IC50=4.79±0.23 μmol/L)
-
Hemolytic Activity
-
- [Ref.22837667]MHC=325.20±0.82 μmol/L against human red blood cells
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18522.
Physicochemical Information
-
Formula
- C145H242N36O34
Absent Amino Acids
- CDEGMNPQRY
Common Amino Acids
- K
Mass
- 3033.74
PI
- 10.78
Basic Residues
- 8
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +8
-
Boman Index
- -2116
Hydrophobicity
- -0.062
Aliphatic Index
- 105
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 220
Polar Residues
- 7
DRAMP18522
Comments Information
Function
- K7D/K10D/K14D/K22D against HeLa cells. D-Lysine replace L-Lysine at the position 7,10,14 and 22 on the polar face of peptide A12L/A20L. Has hemolytic activity.
Literature Information
- ·Literature 1
-
Title
- Role of helicity on the anticancer mechanism of action of cationic-helical peptides.
-
Pubmed ID
- 22837667
-
Reference
- Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.
-
Author
- Huang YB, He LY, Jiang HY, Chen YX.