General Information

    • DRAMP ID

    • DRAMP18538

    • Peptide Name

    • V681

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KWKSFLKTFKSAVKTVLHTALKAISS

    • Sequence Length

    • 26

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=16.0 μg/ml), Staphylococcus aureus SAP0017 (MIC=9.0 μg/ml), Staphylococcus epidermidis C621 (MIC=5.0 μg/ml), Bacillus subtilis C971 (MIC=2.2 μg/ml), Enterococcus faecalis C625 (MIC=16.0 μg/ml), Corynebacterium xerosis C875 (MIC=2.5 μg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=6.3 μg/ml);
      • Gram-negative bacteria: Escherichia coli UB1005 (MIC=7.1 μg/ml), Escherichia coli DC2 (MIC=4.5 μg/ml), Salmonella typhimurium C587 (MIC=20.2 μg/ml), Salmonella typhimurium C610 (MIC=5.7 μg/ml), Pseudomonas aeruginosa H187 (MIC=6.4 μg/ml), Pseudomonas aeruginosa H188 (MIC=20.2 μg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=8.8 μg/ml)

    • Hemolytic Activity

      • [Ref.15677462]MHC=15.6 μg/ml against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18538 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C138H227N35O34

    • Absent Amino Acids

    • CDEGMNPQRY

    • Common Amino Acids

    • K

    • Mass

    • 2920.53

    • PI

    • 10.7

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +7

    • Boman Index

    • -1779

    • Hydrophobicity

    • 0.096

    • Aliphatic Index

    • 93.85

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 220

    • Polar Residues

    • 7

DRAMP18538

DRAMP18538 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.

    • Reference

    • J Biol Chem. 2005 Apr 1;280(13):12316-29.

    • Author

    • Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS.