General Information

    • DRAMP ID

    • DRAMP18558

    • Peptide Name

    • Kn2-7 (BmKn2 peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide BmKn2

    • Gene

    • Not found

    • Sequence

    • FIKRIARLLRKIF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.22792229]Gram-positive bacteria: Staphylococcus aureus AB94004 (MIC=3.13 μg/ml), Staphylococcus aureus ATCC 25923 (MIC=3.13 μg/ml), Bacillus subtilis AB91021 (MIC=6.25 μg/ml), Bacillus thuringiensis AB92037 (MIC=6.25 μg/ml), Micrococcus luteus AB93113 (MIC=6.25 μg/ml);
      • Gram-negative bacteria: Escherichia coli AB94012 (MIC=6.25 μg/ml), Escherichia coli ATCC 25922 (MIC=25 μg/ml), Pseudomonas aeruginosa AB93066 (MIC=25 μg/ml), Pseudomonas aeruginosa A092994 (MIC=50 μg/ml), Pseudomonas aeruginosa A093052 (MIC=100 μg/ml), Pseudomonas aeruginosa A093056 (MIC=50 μg/ml), Pseudomonas aeruginosa A093085 (MIC=50 μg/ml), Pseudomonas aeruginosa A093115 (MIC=100 μg/ml).

    • Hemolytic Activity

      • [Ref.22792229]Non-hemolysis at 6.25 μg/ml, 5% hemolysis at 12.5 μg/ml,10% hemolysis at 25 μg/ml 15% hemolysis at 50 μg/ml, 40% hemolysis at 100 μg/ml against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18558 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18558.

Physicochemical Information

    • Formula

    • C81H140N24O14

    • Absent Amino Acids

    • CDEGHMNPQSTVWY

    • Common Amino Acids

    • IR

    • Mass

    • 1674.15

    • PI

    • 12.31

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +5

    • Boman Index

    • -2349

    • Hydrophobicity

    • 0.554

    • Aliphatic Index

    • 157.69

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP18558

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial activity and mechanism of a scorpion venom peptide derivative in vitro and in vivo.

    • Reference

    • PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135.

    • Author

    • Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z, Li W.