General Information

    • DRAMP ID

    • DRAMP18559

    • Peptide Name

    • HFU3

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • IWRIFRRIF

    • Sequence Length

    • 9

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.22699557]Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=4 μM), Staphylococcus epidermidis ATCC 12228 (MIC=4 μM);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8 μM), Pseudomonas aeruginosa 27853 (MIC=4 μM)

    • Hemolytic Activity

      • [Ref.22699557]MHC=101.4 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18559 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18559.

Physicochemical Information

    • Formula

    • C65H99N19O10

    • Absent Amino Acids

    • ACDEGHKLMNPQSTVY

    • Common Amino Acids

    • IR

    • Mass

    • 1306.62

    • PI

    • 12.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • -2171

    • Hydrophobicity

    • 0.522

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 687.5

    • Polar Residues

    • 0

DRAMP18559

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Biochemical property and membrane-peptide interactions of de novo antimicrobial peptides designed by helix-forming units.

    • Reference

    • Amino Acids. 2012 Dec;43(6):2527-36. doi: 10.1007/s00726-012-1334-7.

    • Author

    • Ma QQ, Dong N, Shan AS, Lv YF, Li YZ, Chen ZH, Cheng BJ, Li ZY.