• • DRAMP ID

  • DRAMP18564

• • Peptide Name

  • MAP-04-03 (Ixosin-B peptide derivative)

• • Source

  • Synthetic construct

• • Family

  • Derived from the peptide Ixosin-B

• • Gene

  • Not found

• • Sequence

  • KWLRRVWRWWR

• • Sequence Length

  • 11

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.22578463]Gram-positive bacterium: Staphylococcus aureus (MIC90=2.5 μM);
    • Gram-negative bacterium: Escherichia coli (MIC90=15 μM), Pseudomonas aeroginosa (MIC90=20 μM)

• • Hemolytic Activity

  • • [Ref.22578463]100% hemolysis at 100μM against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP18564_predicted_structure.pdb to download.

DRAMP18564

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Highly hemolytic activity.

• ·Literature 1

• • Title

  • Discovery of potent antimicrobial peptide analogs of Ixosin-B.

• • Pubmed ID

  • 22578463

• • Reference

  • Bioorg Med Chem Lett. 2012 Jun 15;22(12):4185-8.

• • Author

  • Lung FD, Wang KS, Liao ZJ, Hsu SK, Song FY, Liou CC, Wu YS.