General Information

    • DRAMP ID

    • DRAMP18565

    • Peptide Name

    • MAP-04-04 (Ixosin-B peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide Ixosin-B

    • Gene

    • Not found

    • Sequence

    • KRLRRVWRRWR

    • Sequence Length

    • 11

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.22578463]Gram-positive bacterium: Staphylococcus aureus (MIC90=5 μM);
      • Gram-negative bacterium: Escherichia coli (MIC90=30 μM), Pseudomonas aeroginosa (MIC90=20 μM)

    • Hemolytic Activity

      • [Ref.22578463]3% hemolysis at 100μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18565 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C75H126N32O12

    • Absent Amino Acids

    • ACDEFGHIMNPQSTY

    • Common Amino Acids

    • R

    • Mass

    • 1668.03

    • PI

    • 12.7

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +7

    • Boman Index

    • -8145

    • Hydrophobicity

    • -2.246

    • Aliphatic Index

    • 61.82

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 1100

    • Polar Residues

    • 0

DRAMP18565

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Weak hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Discovery of potent antimicrobial peptide analogs of Ixosin-B.

    • Reference

    • Bioorg Med Chem Lett. 2012 Jun 15;22(12):4185-8.

    • Author

    • Lung FD, Wang KS, Liao ZJ, Hsu SK, Song FY, Liou CC, Wu YS.