• • DRAMP ID

  • DRAMP18566

• • Peptide Name

  • LL-IIIs-1 (lasioglossin III peptide derivative)

• • Source

  • Synthetic construct

• • Family

  • Derived from the peptide lasioglossin III

• • Gene

  • Not found

• • Sequence

  • VNWKKSLGKSIKVVK

• • Sequence Length

  • 15

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

• • Target Organism

  • • [Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=0.7 μM), Bacillus cereus (MIC=0.8 μM), Staphylococcus aureus (MIC=12.5 μM);
    • Gram-negative bacteria: Escherichia coli (MIC=4.4 μM), Pseudomonas aeruginosa (MIC=78.7 μM);
    • Fungi: Candida albicans (MIC=100 μM)

• • Hemolytic Activity

  • • [Ref.22526241]LC50=31.3 μM against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18566.

DRAMP18566

• • Function

  • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.

• ·Literature 1

• • Title

  • Effect of hydrocarbon stapling on the properties of

• • Pubmed ID

  • 22526241

• • Reference

  • Amino Acids. 2012 Nov;43(5):2047-58.

• • Author

  • Chapuis H, Slaninová J, Bednárová L, Monincová L, Buděšínský M, Čeřovský V.