• DRAMP ID

    • DRAMP18568
    • Peptide Name

    • LL-IIIs-3 (lasioglossin III peptide derivative)
    • Source

    • Synthetic construct
    • Family

    • Derived from the peptide lasioglossin III
    • Gene

    • Not found
    • Sequence

    • VSWKKSLGKIIKVVK
    • Sequence Length

    • 15
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal
    • Target Organism

      • [Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1.4 μM), Bacillus cereus (MIC=1.1 μM), Staphylococcus aureus (MIC=21.7 μM);
      • Gram-negative bacteria: Escherichia coli (MIC=1.2 μM), Pseudomonas aeruginosa (MIC=76.3 μM);
      • Fungi: Candida albicans (MIC=93.3 μM)
    • Hemolytic Activity

      • [Ref.22526241]LC50=30 μM against human red blood cells
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Alpha helix
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18568 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C82H145N21O18
    • Absent Amino Acids

    • ACDEFHMNPQRTY
    • Common Amino Acids

    • K
    • Mass

    • 1713.18
    • PI

    • 10.6
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 7
    • Net Charge

    • +5
    • Boman Index

    • -440
    • Hydrophobicity

    • 0.2
    • Aliphatic Index

    • 136
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 392.86
    • Polar Residues

    • 3

DRAMP18568

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.
  • ·Literature 1
    • Title

    • Effect of hydrocarbon stapling on the properties of
    • Reference

    • Amino Acids. 2012 Nov;43(5):2047-58.
    • Author

    • Chapuis H, Slaninová J, Bednárová L, Monincová L, Buděšínský M, Čeřovský V.