General Information
-
DRAMP ID
- DRAMP18569
-
Peptide Name
- LL-IIIs-4 (lasioglossin III peptide derivative)
-
Source
- Synthetic construct
-
Family
- Derived from the peptide lasioglossin III
-
Gene
- Not found
-
Sequence
- VNSKKISGKSIKVSK
-
Sequence Length
- 15
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=2 μM), Bacillus cereus (MIC=1.1 μM), Staphylococcus aureus (MIC=80 μM);
- Gram-negative bacteria: Escherichia coli (MIC=20 μM).
-
Hemolytic Activity
-
- [Ref.22526241]LC50>100 μM against human red blood cells
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18569.
Physicochemical Information
-
Formula
- C70H131N21O21
Absent Amino Acids
- ACDEFHLMPQRTWY
Common Amino Acids
- K
Mass
- 1602.94
PI
- 10.6
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +5
-
Boman Index
- -2913
Hydrophobicity
- -0.613
Aliphatic Index
- 90.67
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP18569
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.
Literature Information
- ·Literature 1
-
Title
- Effect of hydrocarbon stapling on the properties of
-
Pubmed ID
- 22526241
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Reference
- Amino Acids. 2012 Nov;43(5):2047-58.
-
Author
- Chapuis H, Slaninová J, Bednárová L, Monincová L, Buděšínský M, Čeřovský V.