General Information
-
DRAMP ID
- DRAMP18572
-
Peptide Name
- LL-IIIs-6a (lasioglossin III peptide derivative)
-
Source
- Synthetic construct
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Family
- Derived from the peptide lasioglossin III
-
Gene
- Not found
-
Sequence
- VNSKKISPKSIKVSK
-
Sequence Length
- 15
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1 μM), Bacillus cereus (MIC=1.1 μM), Staphylococcus aureus (MIC=93 μM);
- Gram-negative bacteria: Escherichia coli (MIC=7.8 μM), Pseudomonas aeruginosa (MIC=93 μM).
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Hemolytic Activity
-
- [Ref.22526241]LC50>100 μM against human red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
-
Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP18572_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C73H135N21O21
Absent Amino Acids
- ACDEFGHLMQRTWY
Common Amino Acids
- K
Mass
- 1643
PI
- 10.6
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +5
-
Boman Index
- -3007
Hydrophobicity
- -0.693
Aliphatic Index
- 90.67
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP18572
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Effect of hydrocarbon stapling on the properties of
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Pubmed ID
- 22526241
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Reference
- Amino Acids. 2012 Nov;43(5):2047-58.
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Author
- Chapuis H, Slaninová J, Bednárová L, Monincová L, Buděšínský M, Čeřovský V.