General Information
-
DRAMP ID
- DRAMP18575
-
Peptide Name
- MEP-Ns-1 (melectin peptide derivative)
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Source
- Synthetic construct
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Family
- Derived from the peptide melectin
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Gene
- Not found
-
Sequence
- GFLSILKKVLPKSXAHSK
-
Sequence Length
- 18
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal
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Target Organism
-
- [Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=0.8 μM), Bacillus cereus (MIC=1.1 μM), Staphylococcus aureus (MIC=10.8 μM);
- Gram-negative bacteria: Escherichia coli (MIC=2.5 μM), Pseudomonas aeruginosa (MIC=77 μM);
- Fungi: Candida albicans (MIC=30 μM)
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Hemolytic Activity
-
- [Ref.22526241]LC50=18.1 μM against human red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18575.
Physicochemical Information
-
Formula
- C87H147N23O20
Absent Amino Acids
- CDEMNQRTWY
Common Amino Acids
- K
Mass
- 1964.61
PI
- 10.48
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +5
-
Boman Index
- -761
Hydrophobicity
- 0.083
Aliphatic Index
- 108.33
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP18575
Comments Information
Function
- Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Effect of hydrocarbon stapling on the properties of
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Pubmed ID
- 22526241
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Reference
- Amino Acids. 2012 Nov;43(5):2047-58.
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Author
- Chapuis H, Slaninová J, Bednárová L, Monincová L, Buděšínský M, Čeřovský V.