General Information

    • DRAMP ID

    • DRAMP18579

    • Peptide Name

    • MEP-Ns-4 trans (melectin peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide melectin

    • Gene

    • Not found

    • Sequence

    • GFRSILKKVSPKVXAHXK

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=2 μM), Bacillus cereus (MIC=1.7 μM), Staphylococcus aureus (MIC=63 μM);
      • Gram-negative bacteria: Escherichia coli (MIC=16.3 μM).

    • Hemolytic Activity

      • [Ref.22526241]LC50=20 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18579 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18579.

Physicochemical Information

    • Formula

    • C83H139N25O17

    • Absent Amino Acids

    • CDEMNQTWY

    • Common Amino Acids

    • K

    • Mass

    • 2017.87

    • PI

    • 11.33

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +6

    • Boman Index

    • -2493

    • Hydrophobicity

    • -0.311

    • Aliphatic Index

    • 81.11

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP18579

DRAMP18579 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Effect of hydrocarbon stapling on the properties of

    • Reference

    • Amino Acids. 2012 Nov;43(5):2047-58.

    • Author

    • Chapuis H, Slaninová J, Bednárová L, Monincová L, Buděšínský M, Čeřovský V.