General Information
-
DRAMP ID
- DRAMP18580
-
Peptide Name
- MEP-Ns-5 (melectin peptide derivative)
-
Source
- Synthetic construct
-
Family
- Derived from the peptide melectin
-
Gene
- Not found
-
Sequence
- GFLSSLKKSLGKSXAHSK
-
Sequence Length
- 18
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1.5 μM), Bacillus cereus (MIC=1.2 μM), Staphylococcus aureus (MIC=57 μM);
- Gram-negative bacteria: Escherichia coli (MIC=5.6 μM).
-
Hemolytic Activity
-
- [Ref.22526241]LC50=29 μM against human red blood cells
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18580.
Physicochemical Information
-
Formula
- C79H133N23O22
Absent Amino Acids
- CDEIMNPQRTVWY
Common Amino Acids
- S
Mass
- 1886.41
PI
- 10.48
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 5
Net Charge
- +5
-
Boman Index
- -2243
Hydrophobicity
- -0.422
Aliphatic Index
- 70.56
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 7
DRAMP18580
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Effect of hydrocarbon stapling on the properties of
-
Pubmed ID
- 22526241
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Reference
- Amino Acids. 2012 Nov;43(5):2047-58.
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Author
- Chapuis H, Slaninová J, Bednárová L, Monincová L, Buděšínský M, Čeřovský V.