General Information

    • DRAMP ID

    • DRAMP18582

    • Peptide Name

    • CDT (Tachyplesin-1 peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide Tachyplesin-1

    • Gene

    • Not found

    • Sequence

    • KWFRVYRGIYRRR

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.22464970]Non-hemolysis at 200 μg/mL against Not found (The literature does not mention).

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Beta strand

    • Structure Description

    • All of the four Cys residues were deleted from the primary structure of AMP.

    • Helical Wheel Diagram

    • DRAMP18582 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18582.

Physicochemical Information

    • Formula

    • C87H134N30O16

    • Absent Amino Acids

    • ACDEHLMNPQST

    • Common Amino Acids

    • R

    • Mass

    • 1856.21

    • PI

    • 11.84

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +6

    • Boman Index

    • -6522

    • Hydrophobicity

    • -1.446

    • Aliphatic Index

    • 52.31

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 8480

    • Absorbance 280nm

    • 706.67

    • Polar Residues

    • 3

DRAMP18582

Comments Information

    • Function

    • The MIC values of CDT were even found to be lower against Escherichia coli and Listeria monocytogenes in comparison to the native TP-1 peptide. No hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Structure, activity and interactions of the cysteine deleted analog of tachyplesin-1 with lipopolysaccharide micelle: Mechanistic insights into outer-membrane permeabilization and endotoxin neutralization.

    • Reference

    • Biochim Biophys Acta. 2012 Jul;1818(7):1613-24.

    • Author

    • Saravanan R, Mohanram H, Joshi M, Domadia PN, Torres J, Ruedl C, Bhattacharjya S.