• • DRAMP ID

  • DRAMP18587

• • Peptide Name

  • [Arg4,8,13][Lys18]ccTP (ccTP peptide derivative)

• • Source

  • Synthetic construct

• • Family

  • Derived from the peptide ccTP

• • Gene

  • Not found

• • Sequence

  • KWCRCVCRRGICRCRCRK

• • Sequence Length

  • 18

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

• • Target Organism

  • • [Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.7 μM in low-salt; MIC=0.7 μM in high-salt), Micrococcus luteus (MIC=0.3 μM in low-salt; MIC=0.4 μM in high-salt), Enterococcus faecalis (MIC=1.4 μM in low-salt; MIC=1.2 μM in high-salt);
    • Gram-negative bacteria: Escherichia coli (MIC=6.1 μM in low-salt; MIC=1.2 μM in high-salt), Pseudomonas aeruginosa (MIC=2.0 μM in low-salt; MIC=4.7 μM in high-salt), Primula vulgaris (MIC=17.0 μM in low-salt; MIC=39.8 μM in high-salt), Klebsiella oxytoca (MIC=4.1 μM in low-salt; MIC=4.1 μM in high-salt);
    • Fungi: Candida albicans (MIC=10.5 μM in low-salt; MIC=5.2 μM in high-salt), Candida kefyr (MIC=1.1 μM in low-salt; MIC=0.7 μM in high-salt), Candida tropicalis (MIC=2.3 μM in low-salt; MIC=1.9 μM in high-salt).

• • Hemolytic Activity

  • • [Ref.10673369] EC25=3900 μM against human red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • No specific N-terminal

• • C-terminal Modification

  • No specific C-terminal

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18587.

DRAMP18587

• • Function

  • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.

• ·Literature 1

• • Title

  • Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework.

• • Pubmed ID

  • 10673369

• • Reference

  • Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.

• • Author

  • Tam JP, Lu YA, Yang JL.