General Information

    • DRAMP ID

    • DRAMP18588

    • Peptide Name

    • RTD

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFCRCLCRRGVCRCICTK

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

    • Target Organism

      • [Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.1 μM in low-salt; MIC=0.9 μM in high-salt), Micrococcus luteus (MIC=0.5 μM in low-salt; MIC=0.4 μM in high-salt), Enterococcus faecalis (MIC=1.2 μM in low-salt; MIC=1.2 μM in high-salt);
      • Gram-negative bacteria: Escherichia coli (MIC=2.0 μM in low-salt; MIC=28.4 μM in high-salt), Pseudomonas aeruginosa (MIC=2.0 μM in low-salt; MIC=5.2 μM in high-salt), Primula vulgaris (MIC=10.2 μM in low-salt; MIC=50.4 μM in high-salt), Klebsiella oxytoca (MIC=2.0 μM in low-salt; MIC=12.8 μM in high-salt);
      • Fungi: Candida albicans (MIC=4.0 μM in low-salt; MIC=5.2 μM in high-salt), Candida kefyr (MIC=1.8 μM in low-salt; MIC=1.2 μM in high-salt), Candida tropicalis (MIC=2.8 μM in low-salt; MIC=1.0 μM in high-salt).

    • Hemolytic Activity

      • [Ref.10673369]EC25=2350 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18588 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18588.

Physicochemical Information

    • Formula

    • C82H145N31O20S6

    • Absent Amino Acids

    • ADEHMNPQSWY

    • Common Amino Acids

    • C

    • Mass

    • 2077.61

    • PI

    • 9.26

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +5

    • Boman Index

    • -4138

    • Hydrophobicity

    • 0.383

    • Aliphatic Index

    • 59.44

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 22.06

    • Polar Residues

    • 9

DRAMP18588

DRAMP18588 chydropathy plot

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework.

    • Reference

    • Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.

    • Author

    • Tam JP, Lu YA, Yang JL.