General Information

    • DRAMP ID

    • DRAMP18589

    • Peptide Name

    • DSE (Ctx-Ha peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide Ctx-Ha

    • Gene

    • Not found

    • Sequence

    • GWLDVAKKIGKAAFNVAKNFLFNKAVNFAAKGIKKAVDLWG

    • Sequence Length

    • 42

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

    • Target Organism

      • [Ref.22391524]Gram-positive bacterium: Staphylococcus aureus (MIC=8.9 μmol/L; MMC=13.3 μmol/L);
      • Gram-negative bacterium: Escherichia coli (MIC=3.3 μmol/L; MMC=13.3 μmol/L);
      • Fungi: Candida albicans (MIC=53.3 μmol/L; MMC=53.3 μmol/L)

    • Hemolytic Activity

      • [Ref.22391524]HC50=0.6±0.1 μmol/L against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18589 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18589.

Physicochemical Information

    • Formula

    • C212H329N55O49

    • Absent Amino Acids

    • CEHMPQRSTY

    • Common Amino Acids

    • AK

    • Mass

    • 4450.3

    • PI

    • 10.22

    • Basic Residues

    • 8

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 23

    • Net Charge

    • +6

    • Boman Index

    • -1282

    • Hydrophobicity

    • 0.171

    • Aliphatic Index

    • 93.1

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 268.29

    • Polar Residues

    • 8

DRAMP18589

DRAMP18589 chydropathy plot

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha.

    • Reference

    • Antimicrob Agents Chemother. 2012 Jun;56(6):3004-10.

    • Author

    • Lorenzón EN, Cespedes GF, Vicente EF, Nogueira LG, Bauab TM, Castro MS, Cilli EM.