General Information

    • DRAMP ID

    • DRAMP18592

    • Peptide Name

    • Ctx(Ile21)-Ha (Ctx-Ha peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide Ctx-Ha

    • Gene

    • Not found

    • Sequence

    • GWLDVAKKIGKAAFNVAKNFI

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

    • Target Organism

      • [Ref.22519531]Gram-positive bacterium: Staphylococcus aureus (MIC=1 μmol/L);
      • Gram-negative bacteria: Escherichia coli (MIC=4 μmol/L), Pseudomonas aeruginosa (MIC=8 μmol/L);
      • Fungi: Candida albicans (MIC=8 μmol/L), Candida krusei (MIC=8 μmol/L), Candida parapsilosis (MIC=4 μmol/L), Cryptococcus neoformans (MIC=8 μmol/L)

    • Hemolytic Activity

      • [Ref.22519531]HC50=26 μmol/L against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18592 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18592.

Physicochemical Information

    • Formula

    • C109H172N28O26

    • Absent Amino Acids

    • CEHMPQRSTY

    • Common Amino Acids

    • AK

    • Mass

    • 2290.74

    • PI

    • 10

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +3

    • Boman Index

    • -395

    • Hydrophobicity

    • 0.295

    • Aliphatic Index

    • 102.38

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 275

    • Polar Residues

    • 4

DRAMP18592

DRAMP18592 chydropathy plot

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Mechanism of action and relationship between structure and biological activity of Ctx-Ha: a new ceratotoxin-like peptide from Hypsiboas albopunctatus.

    • Reference

    • Protein Pept Lett. 2012 Jun 1;19(6):596-603.

    • Author

    • Cespedes GF, Lorenzón EN, Vicente EF, Mendes-Giannini MJ, Fontes W, Castro MS, Cilli EM.