• • DRAMP ID

  • DRAMP18592

• • Peptide Name

  • Ctx(Ile21)-Ha (Ctx-Ha peptide derivative)

• • Source

  • Synthetic construct

• • Family

  • Derived from the peptide Ctx-Ha

• • Gene

  • Not found

• • Sequence

  • GWLDVAKKIGKAAFNVAKNFI

• • Sequence Length

  • 21

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

• • Target Organism

  • • [Ref.22519531]Gram-positive bacterium: Staphylococcus aureus (MIC=1 μmol/L);
    • Gram-negative bacteria: Escherichia coli (MIC=4 μmol/L), Pseudomonas aeruginosa (MIC=8 μmol/L);
    • Fungi: Candida albicans (MIC=8 μmol/L), Candida krusei (MIC=8 μmol/L), Candida parapsilosis (MIC=4 μmol/L), Cryptococcus neoformans (MIC=8 μmol/L)

• • Hemolytic Activity

  • • [Ref.22519531]HC50=26 μmol/L against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18592.

DRAMP18592

• • Function

  • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.

• ·Literature 1

• • Title

  • Mechanism of action and relationship between structure and biological activity of Ctx-Ha: a new ceratotoxin-like peptide from Hypsiboas albopunctatus.

• • Pubmed ID

  • 22519531

• • Reference

  • Protein Pept Lett. 2012 Jun 1;19(6):596-603.

• • Author

  • Cespedes GF, Lorenzón EN, Vicente EF, Mendes-Giannini MJ, Fontes W, Castro MS, Cilli EM.