General Information

    • DRAMP ID

    • DRAMP18596

    • Peptide Name

    • LL-I/1 (Lasioglossin LL-I peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide Lasioglossin LL-I

    • Gene

    • Not found

    • Sequence

    • NVWKKVLGKIIKVAK

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=1.3 μM), Staphylococcus aureus (MIC=71.6 μM);
      • Gram-negative bacteria: Escherichia coli (MIC=2.5 μM), Pseudomonas aeruginosa (MIC=22.7 μM).

    • Hemolytic Activity

      • [Ref.19591185]LC50>200 μM against rat red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18596 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C83H146N22O17

    • Absent Amino Acids

    • CDEFHMPQRSTY

    • Common Amino Acids

    • K

    • Mass

    • 1724.21

    • PI

    • 10.6

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +5

    • Boman Index

    • -243

    • Hydrophobicity

    • 0.193

    • Aliphatic Index

    • 142.67

    • Half Life

      • Mammalian:1.4 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 2

DRAMP18596

Comments Information

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.

    • Reference

    • Chembiochem. 2009 Aug 17;10(12):2089-2102.

    • Author

    • Cerovský V, Budesínský M, Hovorka O, Cvacka J, Voburka Z, Slaninová J, Borovicková L, Fucík V, Bednárová L, Votruba I, Straka J.