• DRAMP ID

    • DRAMP18607
    • Peptide Name

    • LL-III/4 (Lasioglossin LL-III peptide derivative)
    • Source

    • Synthetic construct
    • Family

    • Derived from the peptide Lasioglossin LL-III
    • Gene

    • Not found
    • Sequence

    • VNWKKILPKIIKVVK
    • Sequence Length

    • 15
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.8 μM), Staphylococcus aureus (MIC=32.5 μM);
      • Gram-negative bacteria: Escherichia coli (MIC=1.2 μM), Pseudomonas aeruginosa (MIC=100 μM).
    • Hemolytic Activity

      • [Ref.19591185]LC50>200 μM against rat red blood cells
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18607 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C89H156N22O17
    • Absent Amino Acids

    • ACDEFGHMQRSTY
    • Common Amino Acids

    • K
    • Mass

    • 1806.35
    • PI

    • 10.6
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +5
    • Boman Index

    • -26
    • Hydrophobicity

    • 0.293
    • Aliphatic Index

    • 162
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 392.86
    • Polar Residues

    • 1

DRAMP18607

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.
  • ·Literature 1
    • Title

    • Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
    • Reference

    • Chembiochem. 2009 Aug 17;10(12):2089-2113.
    • Author

    • Cerovský V, Budesínský M, Hovorka O, Cvacka J, Voburka Z, Slaninová J, Borovicková L, Fucík V, Bednárová L, Votruba I, Straka J.