General Information
-
DRAMP ID
- DRAMP18611
-
Peptide Name
- LL-Ⅲ/8 (Lasioglossin LL-Ⅲ peptide derivative)
-
Source
- Synthetic construct
-
Family
- Derived from the peptide Lasioglossin LL-Ⅲ
-
Gene
- Not found
-
Sequence
- ILGKIIKVVK
-
Sequence Length
- 10
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=40 μM).
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Hemolytic Activity
-
- [Ref.19591185]LC50>200 μM against rat red blood cells
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18611.
Physicochemical Information
-
Formula
- C54H103N13O11
Absent Amino Acids
- ACDEFHMNPQRSTWY
Common Amino Acids
- IK
Mass
- 1110.49
PI
- 10.3
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +3
-
Boman Index
- 1205
Hydrophobicity
- 1.36
Aliphatic Index
- 214
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 1
DRAMP18611
Comments Information
Function
- Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
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Pubmed ID
- 19591185
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Reference
- Chembiochem. 2009 Aug 17;10(12):2089-2117.
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Author
- Cerovský V, Budesínský M, Hovorka O, Cvacka J, Voburka Z, Slaninová J, Borovicková L, Fucík V, Bednárová L, Votruba I, Straka J.