General Information
-
DRAMP ID
- DRAMP18612
-
Peptide Name
- LL-Ⅲ/10 (Lasioglossin LL-Ⅲ peptide derivative)
-
Source
- Synthetic construct
-
Family
- Derived from the peptide Lasioglossin LL-Ⅲ
-
Gene
- Not found
-
Sequence
- KIIKVVK
-
Sequence Length
- 7
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- [Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=100 μM).
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Hemolytic Activity
-
- [Ref.19591185]LC50>200 μM against rat red blood cells
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18612.
Physicochemical Information
-
Formula
- C40H78N10O8
Absent Amino Acids
- ACDEFGHLMNPQRSTWY
Common Amino Acids
- K
Mass
- 827.12
PI
- 10.3
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +3
-
Boman Index
- 127
Hydrophobicity
- 0.814
Aliphatic Index
- 194.29
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP18612
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria.
Literature Information
- ·Literature 1
-
Title
- Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
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Pubmed ID
- 19591185
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Reference
- Chembiochem. 2009 Aug 17;10(12):2089-2119.
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Author
- Cerovský V, Budesínský M, Hovorka O, Cvacka J, Voburka Z, Slaninová J, Borovicková L, Fucík V, Bednárová L, Votruba I, Straka J.