General Information

    • DRAMP ID

    • DRAMP18614

    • Peptide Name

    • TPA (Tritrpticin peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide Tritrpticin

    • Gene

    • Not found

    • Sequence

    • VRRFAWWWAFLRR

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

    • Target Organism

      • [Ref.12207877]Gram-positive bacteria: Bacillus subtilis (MIC=16 μg/ml), Staphylococcus aureus (MIC=32 μg/ml), Staphylococcus epidermidis (MIC=16 μg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=32 μg/ml), Salmonella typhimurium (MIC=32 μg/ml), Pseudomonas aeruginosa (MIC=64 μg/ml);
      • Fungus: Candida albicans (MIC=32 μg/ml).

    • Hemolytic Activity

      • [Ref.12207877]18% hemolysis at 25 μg/ml, 30% hemolysis at 50 μg/ml, 62% hemolysis at 100 μg/ml, 95% hemolysis at 200 μg/ml against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18614 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C92H128N28O14

    • Absent Amino Acids

    • CDEGHIKMNPQSTY

    • Common Amino Acids

    • R

    • Mass

    • 1850.21

    • PI

    • 12.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +4

    • Boman Index

    • -3415

    • Hydrophobicity

    • -0.269

    • Aliphatic Index

    • 67.69

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 16500

    • Absorbance 280nm

    • 1375

    • Polar Residues

    • 0

DRAMP18614

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Conformation-dependent antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide.

    • Reference

    • Biochem Biophys Res Commun. 2002 Sep 6;296(5):1044-50.

    • Author

    • Yang ST, Yub Shin SY, Kim YC, Kim Y, Hahm KS, Kim JI.