• • DRAMP ID

  • DRAMP18615

• • Peptide Name

  • TWF (Tritrpticin peptide derivative)

• • Source

  • Synthetic construct

• • Family

  • Derived from the peptide Tritrpticin

• • Gene

  • Not found

• • Sequence

  • VRRFPFFFPFLRR

• • Sequence Length

  • 13

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

• • Target Organism

  • • [Ref.12207877]Gram-positive bacteria: Bacillus subtilis (MIC=8 μg/ml), Staphylococcus aureus (MIC=16 μg/ml), Staphylococcus epidermidis (MIC=8 μg/ml);
    • Gram-negative bacteria: Escherichia coli (MIC=8 μg/ml), Salmonella typhimurium (MIC=8 μg/ml), Pseudomonas aeruginosa (MIC=16 μg/ml);
    • Fungus: Candida albicans (MIC=16 μg/ml).

• • Hemolytic Activity

  • • [Ref.12207877]Non-hemolysis at 200 μg/ml against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18615.

DRAMP18615

• • Function

  • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. No hemolytic activity.

• ·Literature 1

• • Title

  • Conformation-dependent antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide.

• • Pubmed ID

  • 12207877

• • Reference

  • Biochem Biophys Res Commun. 2002 Sep 6;296(5):1044-50.

• • Author

  • Yang ST, Yub Shin SY, Kim YC, Kim Y, Hahm KS, Kim JI.