• • DRAMP ID

  • DRAMP18616

• • Peptide Name

  • [K22,25,27]-SMAP-29 (SMAP-29 peptide derivative)

• • Source

  • Synthetic construct

• • Family

  • Derived from the peptide SMAP-29

• • Gene

  • Not found

• • Sequence

  • RGLRRLGRKIAHGVKKYGPTVKRIKRKA

• • Sequence Length

  • 28

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

• • Target Organism

  • • [Ref.11467858]Gram-positive bacteria: [No NaCl]: Bacillus subtilis (MIC=6.0 μM), Staphylococcus aureus (MIC=2.0 μM), Micrococcus luteus (MIC=2.0 μM), Staphylococcus epidermidis (MIC=1.0 μM);
    • [100 mM NaCl]: Bacillus subtilis (MIC=4.0 μM), Staphylococcus aureus (MIC=1.0 μM), Micrococcus luteus (MIC=1.0 μM), Staphylococcus epidermidis (MIC=1.0 μM).
    • Gram-negative bacteria: [No NaCl]: Escherichia coli (MIC=6.0 μM), Salmonella typhimurium (MIC=2.0 μM), Pseudomonas aeruginosa (MIC=12.0 μM);[100 mM NaCl]: Escherichia coli (MIC=4.0 μM), Salmonella typhimurium (MIC=1.0 μM), Pseudomonas aeruginosa (MIC=4.0 μM).
    • Fungi: [No NaCl]: Candida albicans (MIC=2.0 μM);[100 mM NaCl]: Candida albicans (MIC=16.0 μM).

• • Hemolytic Activity

  • • [Ref.11467858]Non-hemolysis at 100 μM against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP18616_predicted_structure.pdb to download.

DRAMP18616

• • Function

  • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. No hemolytic activity.

• ·Literature 1

• • Title

  • Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide.

• • Pubmed ID

  • 11467858

• • Reference

  • Biochem Biophys Res Commun. 2001 Jul 27;285(4):1046-51.

• • Author

  • Shin SY, Park EJ, Yang ST, Jung HJ, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI.