General Information

    • DRAMP ID

    • DRAMP18617

    • Peptide Name

    • [A19]-SMAP-29 (SMAP-29 peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide SMAP-29

    • Gene

    • Not found

    • Sequence

    • RGLRRLGRKIAHGVKKYGATVLRIIRIA

    • Sequence Length

    • 28

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal

    • Target Organism

      • [Ref.11467858]Gram-positive bacteria: [No NaCl]: Bacillus subtilis (MIC=4.0 μM), Staphylococcus aureus (MIC=2.0 μM), Micrococcus luteus (MIC=2.0 μM), Staphylococcus epidermidis (MIC=2.0 μM);
      • [100 mM NaCl]: Bacillus subtilis (MIC=2.0 μM), Staphylococcus aureus (MIC=1.0 μM), Micrococcus luteus (MIC=2.0 μM), Staphylococcus epidermidis (MIC=1.0 μM).
      • Gram-negative bacteria: [No NaCl]: Escherichia coli (MIC=4.0 μM), Salmonella typhimurium (MIC=2.0 μM), Pseudomonas aeruginosa (MIC=16.0 μM);[100 mM NaCl]: Escherichia coli (MIC=1.0 μM), Salmonella typhimurium (MIC=1.0 μM), Pseudomonas aeruginosa (MIC=4.0 μM).
      • Fungi: [No NaCl]: Candida albicans (MIC=2.0 μM);[100 mM NaCl]: Candida albicans (MIC=16.0 μM).

    • Hemolytic Activity

      • [Ref.11467858]7% hemolysis at 12.5 μM, 13% hemolysis at 25 μg/ml, 28% hemolysis at 50 μg/ml, 50.4% hemolysis at 100 μg/ml against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18617 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18617.

Physicochemical Information

    • Formula

    • C142H255N51O31

    • Absent Amino Acids

    • CDEFMNPQSW

    • Common Amino Acids

    • R

    • Mass

    • 3172.91

    • PI

    • 12.31

    • Basic Residues

    • 10

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +10

    • Boman Index

    • -6183

    • Hydrophobicity

    • -0.082

    • Aliphatic Index

    • 128.93

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 55.19

    • Polar Residues

    • 6

DRAMP18617

DRAMP18617 chydropathy plot

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide.

    • Reference

    • Biochem Biophys Res Commun. 2001 Jul 27;285(4):1046-51.

    • Author

    • Shin SY, Park EJ, Yang ST, Jung HJ, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI.