General Information
-
DRAMP ID
- DRAMP18620
-
Peptide Name
- Pep-1-K (Pep-1 peptide derivative)
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Source
- Synthetic construct
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Family
- Derived from the peptide Pep-1
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Gene
- Not found
-
Sequence
- KKTWWKTWWTKWSQPKKKRKV
-
Sequence Length
- 21
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.16945333]Gram-positive bacteria: Bacillus subtilis (KCTC 3068) (MIC=2.0 μM), Staphylococcus aureus (KCTC 1621) (MIC=2.0 μM), Staphylococcus epidermidis (KCTC 1917) (MIC=1.0 μM);
- Gram-negative bacteria: Escherichia coli (KCTC 1682) (MIC=2.0 μM), Salmonella typhimurium (KCTC 1926) (MIC=1.0 μM), Pseudomonas aeruginosa (KCTC 1637) (MIC=2.0 μM);
- Antibiotic-resistant bacteria: MRSA 1 (CCARM 3001) (MIC=2.0 μM), MRSA 2 (CCARM 3089) (MIC=2.0 μM), MRSA 3 (CCARM 3543) (MIC=1.0 μM), MDRPA 1 (CCARM 2092) (MIC=8.0 μM), MDRPA 2 (CCARM 2095) (MIC=8.0 μM), MDRPA 3 (CCARM 2109) (MIC=8.0 μM).
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Hemolytic Activity
-
- [Ref.16945333]Non-hemolysis at 200 μM against human red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18620.
Physicochemical Information
-
Formula
- C139H210N38O27
Absent Amino Acids
- ACDEFGHILMNY
Common Amino Acids
- K
Mass
- 2845.44
PI
- 11.51
Basic Residues
- 9
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +9
-
Boman Index
- -6028
Hydrophobicity
- -2.095
Aliphatic Index
- 13.81
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 27500
Absorbance 280nm
- 1375
Polar Residues
- 4
DRAMP18620
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria. No hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Design and mechanism of action of a novel bacteria-selective antimicrobial peptide from the cell-penetrating peptide Pep-1.
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Pubmed ID
- 16945333
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Reference
- Biochem Biophys Res Commun. 2006 Oct 20;349(2):769-74.
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Author
- Zhu WL, Lan H, Park IS, Kim JI, Jin HZ, Hahm KS, Shin SY.