• DRAMP ID

    • DRAMP18620
    • Peptide Name

    • Pep-1-K (Pep-1 peptide derivative)
    • Source

    • Synthetic construct
    • Family

    • Derived from the peptide Pep-1
    • Gene

    • Not found
    • Sequence

    • KKTWWKTWWTKWSQPKKKRKV
    • Sequence Length

    • 21
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.16945333]Gram-positive bacteria: Bacillus subtilis (KCTC 3068) (MIC=2.0 μM), Staphylococcus aureus (KCTC 1621) (MIC=2.0 μM), Staphylococcus epidermidis (KCTC 1917) (MIC=1.0 μM);
      • Gram-negative bacteria: Escherichia coli (KCTC 1682) (MIC=2.0 μM), Salmonella typhimurium (KCTC 1926) (MIC=1.0 μM), Pseudomonas aeruginosa (KCTC 1637) (MIC=2.0 μM);
      • Antibiotic-resistant bacteria: MRSA 1 (CCARM 3001) (MIC=2.0 μM), MRSA 2 (CCARM 3089) (MIC=2.0 μM), MRSA 3 (CCARM 3543) (MIC=1.0 μM), MDRPA 1 (CCARM 2092) (MIC=8.0 μM), MDRPA 2 (CCARM 2095) (MIC=8.0 μM), MDRPA 3 (CCARM 2109) (MIC=8.0 μM).
    • Hemolytic Activity

      • [Ref.16945333]Non-hemolysis at 200 μM against human red blood cells
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18620 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP18620.
    • Formula

    • C139H210N38O27
    • Absent Amino Acids

    • ACDEFGHILMNY
    • Common Amino Acids

    • K
    • Mass

    • 2845.44
    • PI

    • 11.51
    • Basic Residues

    • 9
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Net Charge

    • +9
    • Boman Index

    • -6028
    • Hydrophobicity

    • -2.095
    • Aliphatic Index

    • 13.81
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 27500
    • Absorbance 280nm

    • 1375
    • Polar Residues

    • 4

DRAMP18620

DRAMP18620 chydropathy plot
    • Function

    • Antibacterial activity against Gram-positive bacteria. No hemolytic activity.
  • ·Literature 1
    • Title

    • Design and mechanism of action of a novel bacteria-selective antimicrobial peptide from the cell-penetrating peptide Pep-1.
    • Reference

    • Biochem Biophys Res Commun. 2006 Oct 20;349(2):769-74.
    • Author

    • Zhu WL, Lan H, Park IS, Kim JI, Jin HZ, Hahm KS, Shin SY.