• DRAMP ID

    • DRAMP18623
    • Peptide Name

    • [I5,R8] Mastoparan-L ([I5,R8] MP-L;Mastoparan-L peptide derivative)
    • Source

    • Synthetic construct
    • Family

    • Derived from the peptide Mastoparan
    • Gene

    • Not found
    • Sequence

    • INLKILARLAKKIL
    • Sequence Length

    • 14
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal
    • Target Organism

      • [Ref.27423268]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=25 μM), Streptococcus pyogenes ATCC 19615 (MIC=6.25 μM), Listeria ivanovii Li 4pVS2 (MIC=50 μM);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=6.25 μM), Klebsiella pneumoniae ATCC 13883 (MIC=6.25 μM), Acinetobacter baumannii ATCC 19606 (MIC=3 μM);
      • Fungi: Candida albicans ATCC 90028 (MIC=12.5 μM), Candida parapsilosis ATCC 22019 (MIC=25 μM).
    • Hemolytic Activity

      • [Ref.27423268]LC50>200 μM against rat red blood cells
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Alpha helix
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18623 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C76H143N21O16
    • Absent Amino Acids

    • CDEFGHMPQSTVWY
    • Common Amino Acids

    • L
    • Mass

    • 1607.1
    • PI

    • 11.26
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +4
    • Boman Index

    • -15
    • Hydrophobicity

    • 0.9
    • Aliphatic Index

    • 209.29
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 1

DRAMP18623

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. [Ref.27423268]Cytotoxicity against THP-1-derived macrophages, Weak hemolytic activity.
  • ·Literature 1
    • Title

    • Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan.
    • Reference

    • Biochim Biophys Acta. 2016 Nov;1858(11):2699-2708.
    • Author

    • Irazazabal LN, Porto WF, Ribeiro SM, Casale S, Humblot V, Ladram A, Franco OL.