• • DRAMP ID

  • DRAMP18629

• • Peptide Name

  • D9-K9L8W-1 (D-amino acid substitution of K9L8W)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • KLKKLLKKWLKLLKKLLK

• • Sequence Length

  • 18

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.20363271]Gram-positive bacteria: Bacillus subtilis (MIC=1 μM), Staphylococcus epidermidis (MIC=4 μM), Staphylococcus aureus (MIC=4 μM);
    • Gram-negative bacteria: Escherichia coli (MIC=2 μM), Pseudomonas aeruginosa (MIC=2 μM), Salmonella typhimurium (MIC=2 μM).

• • Hemolytic Activity

  • • [Ref.20363271]HC50>800 μM against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18629.

DRAMP18629

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. D-Leucine replace L-Leucine at the position 2,6,10,12 and 16 on the peptide K9L8W, D-Lysine replace L-Lysine at the position 4,8,14 and 18 on the peptide K9L8W. Weak hemolytic activity.

• ·Literature 1

• • Title

  • Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides.

• • Pubmed ID

  • 20363271

• • Reference

  • Peptides. 2010 Jul;31(7):1251-61.

• • Author

  • Wang P, Nan YH, Yang ST, Kang SW, Kim Y, Park IS, Hahm KS, Shin SY.