General Information

    • DRAMP ID

    • DRAMP18631

    • Peptide Name

    • H5(61–90) V1 (Histone H5 peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from Histone H5

    • Gene

    • Not found

    • Sequence

    • VGHNADLQIKLSIRRLLAAGVLKQTKGVGA

    • Sequence Length

    • 30

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.29402952] Gram-positive bacteria: Listeria monocytogenes (MIC=23.1±8.1 μg/mL);
      • Gram-negative bacterium: Pseudomonas aeruginosa (MIC=16±0 μg/mL)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix, Random coil

    • Structure Description

    • The peptide adopts a random coil structure in water and presented an orders alpha-helix structure with 84.2 % alpha-helices in 30?mM SDS

    • Helical Wheel Diagram

    • DRAMP18631 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18631.

Physicochemical Information

    • Formula

    • C138H244N44O38

    • Absent Amino Acids

    • CEFMPWY

    • Common Amino Acids

    • L

    • Mass

    • 3127.73

    • PI

    • 11.1

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +5

    • Boman Index

    • -2600

    • Hydrophobicity

    • 0.227

    • Aliphatic Index

    • 133.33

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP18631

DRAMP18631 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria. H5(61

Literature Information

  • ·Literature 1

    • Title

    • Histone H5 is a potent Antimicrobial Agent and a template for novel Antimicrobial Peptides.

    • Reference

    • Sci Rep. 2018 Feb 5;8(1):2411.

    • Author

    • Jodoin J, Hincke MT.