General Information

    • DRAMP ID

    • DRAMP18632

    • Peptide Name

    • Peptide H5 (71-90) (Histone H5 peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from Histone H5

    • Gene

    • Not found

    • Sequence

    • LSIRRLLAAGVLKQTKGVGA

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.29402952] Gram-negative bacterium: Pseudomonas aeruginosa (MIC=26.7±14.1 μg/mL)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18632 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18632.

Physicochemical Information

    • Formula

    • C91H167N29O24

    • Absent Amino Acids

    • CDEFHMNPWY

    • Common Amino Acids

    • L

    • Mass

    • 2051.51

    • PI

    • 12.02

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +4

    • Boman Index

    • -1152

    • Hydrophobicity

    • 0.525

    • Aliphatic Index

    • 141.5

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP18632

DRAMP18632 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Histone H5 is a potent Antimicrobial Agent and a template for novel Antimicrobial Peptides.

    • Reference

    • Sci Rep. 2018 Feb 5;8(1):2411.

    • Author

    • Jodoin J, Hincke MT.