General Information
-
DRAMP ID
- DRAMP18633
-
Peptide Name
- H5(61-90) V2 (Histone H5 peptide derivative)
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Source
- Synthetic construct
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Family
- Derived from Histone H5
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Gene
- Not found
-
Sequence
- VGHNADLQIKLSIRRLLAAGVLKQTKGVGA
-
Sequence Length
- 30
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- [Ref.29402952] Gram-negative bacterium: Pseudomonas aeruginosa (MIC=33.8 ± 26.3 μg/mL)
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Alpha helix, Random coil
-
Structure Description
- The peptide adopts a random coil structure in water and presented an orders alpha-helix structure with 75.5 % alpha-helices in 30?mM SDS
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18633.
Physicochemical Information
-
Formula
- C138H244N44O38
Absent Amino Acids
- CEFMPWY
Common Amino Acids
- L
Mass
- 3127.73
PI
- 11.1
Basic Residues
- 6
Acidic Residues
- 1
Hydrophobic Residues
- 14
Net Charge
- +5
-
Boman Index
- -2600
Hydrophobicity
- 0.227
Aliphatic Index
- 133.33
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 7
DRAMP18633
Comments Information
Function
- Antibacterial activity against Gram-negative bacteria. H5(61
Literature Information
- ·Literature 1
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Title
- Histone H5 is a potent Antimicrobial Agent and a template for novel Antimicrobial Peptides.
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Pubmed ID
- 29402952
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Reference
- Sci Rep. 2018 Feb 5;8(1):2411.
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Author
- Jodoin J, Hincke MT.