General Information

    • DRAMP ID

    • DRAMP18635

    • Peptide Name

    • NCP-0

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KLIPIASKTCPAGKNLCYKI

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.29364903] Gram-negative bacteria: Burkholderia cepacia ATCC 17759(MBC=50μg/ml);Moraxella catarrhalis ATCC 25238(MBC=1.6μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Unordered structure

    • Structure Description

    • The peptide adopts overall content of unordered secondary structure that is 67%

    • Helical Wheel Diagram

    • DRAMP18635 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18635.

Physicochemical Information

    • Formula

    • C98H169N25O25S2

    • Absent Amino Acids

    • DEFHMQRVW

    • Common Amino Acids

    • K

    • Mass

    • 2161.69

    • PI

    • 9.6

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • -323

    • Hydrophobicity

    • 0.21

    • Aliphatic Index

    • 107.5

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 85

    • Polar Residues

    • 7

DRAMP18635

DRAMP18635 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity.

    • Reference

    • PLoS One. 2018 Jan 24;13(1):e0190778.

    • Author

    • Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, Taddei S.