General Information
-
DRAMP ID
- DRAMP18636
-
Peptide Name
- NCP-3a (CTX-1 peptide derivative)
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Source
- Synthetic construct
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Family
- Derived from CTX-1
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Gene
- Not found
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Sequence
- KLIFILSKTIPAGKNLFYKI
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.29364903] Gram-positive bacteria: Methicillin-resistant Staphylococcus aureus ATCC 43300 (MBC=6.3 μg/ml), Staphylococcus aureus ATCC 22953 (MBC=12.5 μg/ml), Enterococcus hirae ATCC 10541 (MBC=6.3 μg/ml), Streptococcus agalactiae ATCC 13813 (MBC=3.1 μg/ml);
- Gram-negative bacterium: Escherichia coli ATCC 25922 (MBC=6.3 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MBC=25 μg/ml), Acinetobacter baumannii (ornithological, cloacal) (MBC=25 μg/ml), Acinetobacter baumannii (human, urinary) (MBC=25 μg/ml), Klebsiella pneumoniae subsp. pneumoniae (herpetological, cloacal) (MBC=50 μg/ml), Burkholderia cepacia ATCC 17759 (MBC=50 μg/ml), Moraxella catarrhalis ATCC 25238 (MBC=3.1 μg/ml);
- Fungi: Candida albicans ATCC 10231 (MBC=6.3 μg/mL), Candida glabrata ATCC 90030 (MBC=25 μg/mL), Malassezia pachydermatis DSMZ 6172 (MBC=6.3 μg/mL)
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18636.
Physicochemical Information
-
Formula
- C114H187N25O25
Absent Amino Acids
- CDEHMQRVW
Common Amino Acids
- IK
Mass
- 2307.89
PI
- 10.18
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 10
Net Charge
- +4
-
Boman Index
- 820
Hydrophobicity
- 0.645
Aliphatic Index
- 141.5
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 78.42
Polar Residues
- 5
DRAMP18636
Comments Information
Function
- Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.
Literature Information
- ·Literature 1
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Title
- Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity.
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Pubmed ID
- 29364903
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Reference
- PLoS One. 2018 Jan 24;13(1):e0190778.
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Author
- Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, Taddei S.