• DRAMP ID

    • DRAMP18637
    • Peptide Name

    • NCP-3b (CTX-1 peptide derivative)
    • Source

    • Synthetic construct
    • Family

    • Derived from CTX-1
    • Gene

    • Not found
    • Sequence

    • KLILILSKTIPAGKNLFYKI
    • Sequence Length

    • 20
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.29364903] Gram-positive bacteria: Methicillin-resistant Staphylococcus aureus ATCC 43300 (MBC=6.3 μg/ml), Staphylococcus aureus ATCC 22953 (MBC=50 μg/ml), Enterococcus hirae ATCC 10541 (MBC=12.5 μg/ml), Streptococcus agalactiae ATCC 13813 (MBC=12.5 μg/ml);
      • Gram-negative bacterium: Escherichia coli ATCC 25922 (MBC=12.5 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MBC=25 μg/ml), Acinetobacter baumannii (ornithological, cloacal) (MBC=25 μg/ml), Acinetobacter baumannii (human, urinary) (MBC=25 μg/ml), Klebsiella pneumoniae subsp. pneumoniae (herpetological, cloacal) (MBC=25 μg/ml), Burkholderia cepacia ATCC 17759 (MBC=25 μg/ml), Moraxella catarrhalis ATCC 25238 (MBC=12.5 μg/ml);
      • Fungi: Candida albicans ATCC 10231 (MBC=12.5 μg/mL), Candida glabrata ATCC 90030 (MBC=100 μg/mL), Malassezia pachydermatis DSMZ 6172 (MBC=25 μg/mL)
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Alpha helix
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18637 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP18637.
    • Formula

    • C111H189N25O25
    • Absent Amino Acids

    • CDEHMQRVW
    • Common Amino Acids

    • IKL
    • Mass

    • 2273.87
    • PI

    • 10.18
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +4
    • Boman Index

    • 1014
    • Hydrophobicity

    • 0.695
    • Aliphatic Index

    • 161
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 78.42
    • Polar Residues

    • 5

DRAMP18637

DRAMP18637 chydropathy plot
    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.
  • ·Literature 1
    • Title

    • Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity.
    • Reference

    • PLoS One. 2018 Jan 24;13(1):e0190778.
    • Author

    • Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, Taddei S.