General Information

    • DRAMP ID

    • DRAMP18638

    • Peptide Name

    • VT18-LV (VT18 peptide derivative)

    • Source

    • Synthetic construct

    • Family

    • Derived from VT18

    • Gene

    • Not found

    • Sequence

    • VYPFMWGGAYCFCDAELV

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Ref.29277569] Gram-positive bacteria: Streptococcus pneumoniae ATCC 700669 (MIC=207 μg/ml)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Double-stranded

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18638 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18638.

Physicochemical Information

    • Formula

    • C98H131N19O25S3

    • Absent Amino Acids

    • HIKNQRST

    • Common Amino Acids

    • ACFGVY

    • Mass

    • 2071.41

    • PI

    • 3.67

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • -2

    • Boman Index

    • 1589

    • Hydrophobicity

    • 0.856

    • Aliphatic Index

    • 65

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 8605

    • Absorbance 280nm

    • 506.18

    • Polar Residues

    • 6

DRAMP18638

DRAMP18638 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Membrane permeabilization design of antimicrobial peptides based on chikungunya virus fusion domain scaffold and its antibacterial activity against gram-positive Streptococcus pneumoniae in respiratory infection.

    • Reference

    • Biochimie. 2018 Mar;146:139-147.

    • Author

    • Yang R, Zhang G, Zhang F, Li Z, Huang C.