General Information
-
DRAMP ID
- DRAMP18639
-
Peptide Name
- CTO17 (TO17 peptide derivative)
-
Source
- Synthetic construct
-
Family
- Derived from TO17
-
Gene
- Not found
-
Sequence
- CKCRRRKVHGPMIRIRKK
-
Sequence Length
- 18
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- [Ref.29183811] Gram-negative bacterium: Vibrio vulnificus (MIC=20 μM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18639.
Physicochemical Information
-
Formula
- C95H177N39O19S3
Absent Amino Acids
- ADEFLNQSTWY
Common Amino Acids
- R
Mass
- 2265.88
PI
- 11.85
Basic Residues
- 10
Acidic Residues
- 0
Hydrophobic Residues
- 3
Net Charge
- +10
-
Boman Index
- -8173
Hydrophobicity
- -1.289
Aliphatic Index
- 59.44
Half Life
-
- Mammalian:1.2 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 7.35
Polar Residues
- 3
DRAMP18639
Comments Information
Function
- Antibacterial activity against the Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- TO17: A teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus.
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Pubmed ID
- 29183811
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Reference
- Fish Shellfish Immunol. 2018 Jan;72:639-645.
-
Author
- He SW, Wang GH, Yue B, Zhou S, Zhang M.